Hi Jack,
for one of my projects I keep the dlls in two different folders and decide with mode64bit what dll to use:
$ filename "HelloWorld1.exe"
'uses rtl32
'uses rtl64
includepath "../include/"  
#ifndef mode64bit     
   extern lib "../IUP32/iup.dll" 
   uses "iup.h"   
   end extern
   extern cdecl
#else
   extern lib "../IUP64/iup.dll" 
   uses "iup.h"    
end extern 
#endif
sub main()
  IupOpen(0,0)  
  IupMessage("Hello World 1", "Hello world from IUP.") 
  IupClose()
end sub
main()
I suppose there are some more options.
You can also find examples of using mode64bit e.g. in \inc\Msvcrt.inc and inc\MinWin.inc
Roland